Monday, October 20, 1997
Pharmacogenomics, the search for individual factors that influence
responses to drug treatment, depends on the identification of the genes responsible for
individual differences. Last week's issues of the Journal of the American Medical
Association and Human Molecular Genetics contained several reports that
highlight progress in the understanding of the effects of individual genetic background on
susceptibility to disease.
Identification of susceptibility genes may appear to cloud the picture
of disease physiology, but in some cases adding more genes to the puzzle can focus
attention on one point for therapeutic intervention.