BioCentury on BioBusiness,
Pharma venture arms take a stake in gene therapy play Celladon
Funding the white space
Monday, March 5, 2012
Corp. found no pharma partners for its Mydicar gene therapy following
data from a small Phase I/II trial in advanced heart failure patients, but the
results prompted the venture arms of three of the pharmas to take a stake in
the biotech based on early signs of efficacy in a population with few options.
Mydicar is a recombinant
adeno-associated viral (AAV) vector carrying the gene for sarcoplasmic
reticulum ATPase Ca++ transporting cardiac muscle slow twitch 2 (ATP2A2;
SERCA2A). The gene is a regulator of myocardial contractility.
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