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Product Discovery & Development
How AZ's olaparib combinations may produce large PFS gains in ovarian cancer
Related tables, figures and sidebars
Sum of PARPs
Monday, June 9, 2014
Data for olaparib plus cediranib presented at the American
Society of Clinical Oncology meeting show the ovarian cancer therapies may
be able to achieve unprecedented gains in progression-free survival when used
in combination. Whether the combination catches on will depend on how well
physicians can manage the regimen's increased toxicity over olaparib
monotherapy, and whether patients are willing to undergo the higher side effect
In combination, AstraZeneca
plc's compounds led to an eight-month PFS benefit over olaparib
monotherapy, according to interim data from a 90-patient Phase II trial in
women with recurrent platinum-sensitive ovarian cancer. The National
Cancer Institute sponsored the study.
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