Acacia Pharma Ltd. was searching for a safer version of droperidol, which is efficacious in preventing postoperative nausea and vomiting but not often used due to safety issues. Now Phase II data show APD421 actually may be more efficacious as well as safer.

Anesthesiologists have multiple options for preventing and treating postoperative nausea and vomiting (PONV), including dopamine receptor antagonists such as droperidol and serotonin (5-HT3) receptor antagonists such as ondansetron.