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Product Discovery & Development
Exelixis: Cabozantinib will vie with AstraZeneca's Caprelsa in thyroid cancer
Mixed messages in MTC
Monday, June 4, 2012
Updated Phase III data for Exelixis
Inc.'s cabozantinib showed the compound did not improve survival in
patients with medullary thyroid cancer, but the biotech says the data are not
mature and that PFS and safety data suggest its compound could be competitive
plc's Caprelsa vandetanib.
About 2,000 patients are
diagnosed with MTC in the U.S. each year. The initial treatment is removal of
the thyroid, after which some patients may have relatively indolent disease and
others will experience highly progressive metastatic disease over the course of
months. The exact proportion of patients with highly progressive disease is unknown.
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