BioCentury on BioBusiness,
Product Discovery & Development
Sernova's Cell Pouch, Sertoli cells protect implanted islet cells in diabetes
Monday, May 28, 2012
Corp. is developing its Sertolin
cell technology and Cell Pouch System device to provide an immune-privileged,
vascularized environment for donor islet cells to produce insulin in
insulin-dependent diabetes patients. The approach is intended to overcome
problems with traditional islet cell transplantation, including poor rates of
cell survival and engraftment, and unwanted immune responses.
Standard islet transplantation
involves using a catheter to infuse islet cells into the portal vein of the
liver. While minimally invasive, the procedure carries the risk of portal vein
thrombosis and intraperitoneal bleeding.
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