BioCentury on BioBusiness,
Product Discovery & Development
Roche's dalcetrapib failure fuels HDL debate, but CETP not done yet
CETP strike two
By Chris Cain
Senior Writer
Published on
Monday, May 21, 2012
A discontinued Phase III trial of Roche's
dalcetrapib provides the largest look at cardiovascular outcomes associated
with CETP inhibition since the failure of Pfizer
Inc.'s torcetrapib more than five years ago. Unfortunately, a lack of
detailed data coupled with compound-specific issues means the debate over the
target will likely continue until Merck & Co. Inc. produces
outcomes data for its anacetrapib after 2015.
When Pfizer
dropped torcetrapib in 2006 because of an increase in mortality in Phase III
trials, other companies working on compounds that inhibit cholesteryl ester
transfer protein (CETP) argued torcetrapib's problems were compound-specific
and that different compounds bound the target in different ways (see
BioCentury, Dec. 11, 2006).
111
words displayed of
1784
words total.
To read this article, you must be an Archives subscriber. Please choose one of the options below.
All contents Copyright © 1993-2013 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement and the BioCentury Terms of Use. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions at www.biocentury.com. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
|
Current Subscribers
If you are a current subscriber, log in below or in the upper right corner of this
page.
Log In
Subscription Option
Whether you want an individual subscription or need a global group license, we have the products,
the experience and the customer support that biopharma executives, researchers, investors, service providers,
and industry stakeholders have trusted for nearly two decades.
Let our Subscriber Services team customize the best intelligence package available in the industry to meet your needs.
Free Trial 4 Weeks of Access
Get a 4-week free trial subscription to see the important articles you are missing.
Get 4 Weeks Free
Thank You
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
records.
close [ X ]