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Beyond statins: PCSK9 inhibitors slash LDL; but not for all patients
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Beyond statins: LDL diversity
By Michael Flanagan
Senior Writer
Published on
Monday, April 30, 2012
No fewer than 20 companies are
working on next-generation lipid-lowering agents intended to improve upon the
benefits of statins, which lower LDL-C and reduce the risk of cardiovascular
events but still leave millions of people above target LDL-C levels. While most
are developing their compounds in similar settings - generally as add-ons to
high-dose statins in patients not achieving LDL-C goals - emerging data suggest
different mechanisms may turn out to be appropriate for different populations.
In March two mAbs that inhibit
proprotein convertase subtilisin/kexin 9 made headlines with new clinical data.
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