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Bad dog results for Karo Bio could hinder biotechs working on TR beta agonists
Cartilage damage dilemma
Monday, February 27, 2012
The unexpected finding of cartilage damage in a preclinical
toxicity study of Karo
Bio AB's eprotirome may make it hard for other companies working on thyroid
hormone receptor beta agonists to find partners, unless further data reveal it
is a compound rather than a class problem.
Earlier this month, Karo Bio
said a 12-month toxicology study in dogs showed all animals receiving the
highest dose of eprotirome had cartilage damage, as well as some dogs given
lower doses of the compound. Control animals showed no damage.
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