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Product Discovery & Development
Elusive anxiety relief
Monday, December 24, 2001
Results from two Phase II trials of partial GABA-A selective receptor agonists indicate that subtle differences in receptor selectivity can have significant clinical effects.
Neurogen Corp.'s NGD91-3 small molecule GABA-A partial agonist did not meet its primary endpoint of reduction in the physician-reported HAM-A anxiety score in patients with generalized anxiety disorder (GAD). But Interneuron Pharmaceuticals Inc. reported results of a similar 6-week study in GAD patients in which its pagoclone GABA-A partial agonist did provide significant reductions in HAM-A score from baseline compared to placebo (see B13).
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