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amcure angiogenesis inhibitor aims to improve tolerability and halt metastasis
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amcure: Reimagining angiogenesis
Monday, July 28, 2014
GmbH is developing peptide-based inhibitors of CD44v6, a
tumor-specific co-receptor of tyrosine kinases including VEGFR-2 and c-Met. The
approach could allow for higher dosing with fewer side effects than
direct-acting tyrosine kinase inhibitors, while beating back the formation of
CEO Matthias Klaften, the peptide drug candidates that
target splice variant v6 of CD44 (CD44v6) show a "really astonishing
effect on the formation of metastases" plus regression of already
established metastases. "We do also see a very strong effect on the
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