Insulin-dependent diabetics take a combination of basal and prandial insulins two or more times a day to manage fluctuations in blood sugar, especially at mealtime. Sensulin LLC is developing a glucose-responsive once-daily insulin that could mimic insulin release in healthy people and eliminate the need for multiple injections.

Basal insulins are taken once a day, and prandial insulins are added at mealtimes, or whenever a surge in glucose is expected. There are premixed products that combine prandial and basal insulin; however, they require twice-daily injections to maintain basal insulin levels.