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Aeglea's engineered human enzymes starve tumors
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Aeglea: Old enzymes, new tricks
Monday, April 28, 2014
BioTherapeutics Holdings LLC is developing enzymes to starve tumors
that depend on outside sources of specific amino acids. Aeglea's engineered
human enzymes may offer lower immunogenicity and greater activity than natural
versions further along in development.
Since the 1990s, clinicians
have used asparaginase enzymes to treat acute lymphoblastic leukemia (ALL). For
reasons not yet understood, ALL cells tend to lose their ability to make
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