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Meditope keyhole linker creates homogeneous antibody-drug conjugates
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Meditope: Keyhole conjugation
Monday, November 18, 2013
Biosciences Inc.'s meditope-enabled linker technology could improve
upon first-generation antibody-drug conjugates by producing ADCs that are more
stable and homogeneous.
technologies typically link cytotoxic agents to naturally occurring
amino acids on mAbs, such as cysteine or lysine. Because any given mAb contains
numerous cysteine and lysine sequences, conjugating the payload to a naturally
occurring amino acid can result in a heterogeneous drug mixture. Some mAbs may
have no cytotoxic drugs attached, while others in the same product may have six
or more linked payloads.
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