BioCentury on BioBusiness,
Emerging Company Profile
Meditope keyhole linker creates homogeneous antibody-drug conjugates
Related tables, figures and sidebars
Meditope: Keyhole conjugation
Monday, November 18, 2013
Biosciences Inc.'s meditope-enabled linker technology could improve
upon first-generation antibody-drug conjugates by producing ADCs that are more
stable and homogeneous.
technologies typically link cytotoxic agents to naturally occurring
amino acids on mAbs, such as cysteine or lysine. Because any given mAb contains
numerous cysteine and lysine sequences, conjugating the payload to a naturally
occurring amino acid can result in a heterogeneous drug mixture. Some mAbs may
have no cytotoxic drugs attached, while others in the same product may have six
or more linked payloads.
words displayed of
To read this article, you must be an Archives subscriber. Please choose one of the options below.
All contents Copyright © 1993-2016 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Whether you want an individual subscription or need a global group license, we have the products,
the experience and the customer support that biopharma executives, researchers, investors, service providers,
and industry stakeholders have trusted for nearly two decades.
Let our Subscriber Services team customize the best intelligence package available in the industry to meet your needs.
Free Trial Subscription 4 Weeks of Access
BioCentury's Weekly Business Intelligence Journal
Get a 4-week free trial subscription to BioCentury.
Get 4 Weeks Free
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]