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Allena develops enzymes for hyperoxaluria, linked to kidney stones, GI disorders
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Allena: Degrading in the gut
Monday, December 3, 2012
Pharmaceuticals Inc. is developing a recombinant version of an
undisclosed enzyme that degrades oxalate in the GI tract to treat
hyperoxaluria, a metabolic disease for which there are no therapies. It
believes the enzyme could have manufacturing advantages over the most advanced
competitor, which is a probiotic.
There are two forms of hyperoxaluria. Primary hyperoxaluria is
an autosomal recessive disease affecting 5,000-7,000 patients worldwide.
Hepatic enzyme deficiencies in glyoxylate metabolism lead to increased
endogenous oxalate synthesis and the buildup of calcium oxalate crystals in the
kidneys. Subsequent renal failure occurs in 50% of patients by age 15 and 80%
of patients by age 30, according to The
Oxalosis & Hyperoxaluria Foundation. Those patients will
need kidney and liver transplantation.
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