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Regenesance developing anti-C6 mAbs for myasthenia gravis
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Regenesance: Stopping the MAC attack
Monday, October 29, 2012
B.V. is developing mAbs against complement 6 that may halt nerve damage
and provide a better safety profile than standard of care for the orphan
neurological disease myasthenia gravis. The mAbs are in lead optimization and
are expected to enter the clinic in 18 months.
Myasthenia gravis is an
autoimmune disorder characterized by a loss of signaling between nerve and
muscle cells that leads to muscle weakness. The disease can be life
threatening, as muscle weakness in the diaphragm can lead to breathing
difficulty and the need for respiratory support.
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