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Actium screens for compounds to selectively target cancer stem cells for chemo
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Stem Cell Differentiator
By Tim Fulmer
Senior Writer
Published on
Monday, September 10, 2012
While most companies working on cancer stem cells appear to be
developing compounds to kill the cells themselves, Actium
Research Inc. is working on ways to make these cells vulnerable to
chemotherapy. The company's screening platform is designed to identify small
molecules that induce differentiation in cancer stem cells but not normal stem cells.
Cancer stem cells are a
subpopulation of tumor cells that remain in a pluripotent state and are thought
to initiate and sustain tumor growth. Multiple lines of evidence suggest these
cells evade chemotherapy, which primarily kills differentiated cells in
the
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