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Lanthio's stabilization technology aims to optimize efficacy of peptides
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Lanthio: Bacterial stabilization
By Stephen Hansen
Senior Writer
Published on
Monday, February 20, 2012
A major drawback of therapeutic peptides is their rapid
degradation and loss of function in the body. Lanthio
Pharma B.V. has developed its bacteria-based peptide stabilization
technology to provide libraries of peptides that are resistant to degradation,
structured to improve efficacy and can be administered via oral or pulmonary
delivery.
The basis of the company's
technology is Lactococcus lactis, a bacterium that produces peptides
containing lanthionine bridges. A lanthionine is composed of two alanine
residues that are cross-linked by a thioether bond. Lanthionine bridges can
span from two to 10 amino acids, and lock the resulting peptide into a specific
conformation.
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