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Cantargia mAb against CML stem cells could be curative, cost-effective vs. TKIs
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Cantargia: Stemming CML
By Stephen Hansen
Senior Writer
Published on Monday, January 30, 2012
Tyrosine kinase inhibitors have turned chronic myelogenous
leukemia into a chronic disease for many patients, but imposes a financial
burden on payers. Cantargia
AB thinks that targeting CML stem cells can provide a cost-effective,
curative therapy.
The majority of CML cases are characterized by cells carrying
the Philadelphia chromosome, which encodes the oncogenic BCR-ABL fusion
protein. The gold standard treatments for CML are TKIs that target BCR-ABL:
Gleevec imatinib and Tasigna nilotinib from Novartis
AG and Sprycel dasatinib from Bristol-Myers
Squibb Co.
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