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CytomX expects targeted Probodies will be safer than mAbs; starting with cancer
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CytomX: Probody building
By Andrew Fisher
Staff Writer
Published on
Monday, May 2, 2011
mAbs have revolutionized targeted therapy but still often
cause side effects when the target is expressed in healthy tissue. CytomX
Therapeutics Inc. thinks its Probodies will get around those safety
issues because they are activated locally at the site of disease.
CytomX expects the
proteolytically activated antibody technology to result in compounds with an
improved therapeutic index against validated targets, as well as compounds
against targets previously thought to be undruggable because they are expressed
in diseased and healthy tissue.
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