The generation of mutant bacteria and yeast to study biological pathways, ultimately leading to the isolation of relevant genes through functional cloning, is well established. However, analogous technologies for use in mammalian cells lag far behind, owing primarily to the asexual nature of these cells in tissue culture.

Furthermore, while genomic sequencing and positional cloning can identify many human genes, there is a gap between the gene sequences and the amount of corresponding functional information gleaned from them. Genetica Inc. applies its technology toward the genetic manipulation of mammalian cells in tissue culture to elucidate biological pathways, thereby assigning function to genetic information.