Monday, April 21, 1997
The star Rigel, used by
sailors for navigation, is in the constellation Orion, also known as "The
Hunter." While Rigel's constellation hunts Taurus the bull, Rigel Inc. is
hunting signaling pathways and targets for drug development using libraries of
peptide-encoding retroviruses. The company plans to apply its technology in
cell-based assays relevant to several disease processes.
Co-founder Garry Nolan,
of the department of molecular pharmacology and gene therapy center of Stanford
University, has established methods for creating up to 5 billion different
retroviruses that contain distinct peptides that can infect individual cells in
culture. This leads to a collection of cells, either primary culture or
established cell lines, where each cell expresses a unique peptide.