Jennifer Doudna and Emmanuelle Charpentier have won the 2020 Nobel Prize in Chemistry eight years after their joint discovery that the CRISPR-Cas9 bacterial immune defense system can be harnessed...

A report released Wednesday by an expert panel on human germline editing is the first to go beyond calls for caution and consensus and start to spell out technical definitions of safety.  Like every other...

Single cell pioneer Aviv Regev thinks the gene networks revealed by the technology are on the verge of delivering new ways to attack disease biology. Her emphasis is on the idea that uncovering how genes...

Two studies published this week advance the search for blood tests for Alzheimer’s disease, but it’s not yet clear how transformative the plasma markers will be. Both studies came to the same conclusion: one form...

CRISPR pioneer Jennifer Doudna is adding a Cas protein to the toolbox with features that could make it a good gene editing tool. In a Science paper published on Thursday, the University of California Berkeley...

David Liu and colleagues at the Broad Institute and University of Washington have achieved single-base editing of mitochondrial DNA for the first time, overcoming a limitation of CRISPR-based technologies and opening up new avenues for...

In the latest example of a regenerative medicine approach that involves transforming one cell type in the body into another, a University of California San Diego team has shown it can replace lost dopamine neurons...

Making machine learning an effective tool in the fight against COVID-19 requires broad access to data, scrupulous checks for bias, and strategies to balance speed and accuracy, according to researchers with AI-based diagnostics and literature-mining...

Spark aims to solve one of the big problems plaguing gene therapy -- immune responses against viral vectors -- by adapting a strategy Hansa has been developing for transplant rejection. Past infections with adenoviruses or...

Denali is lifting the veil on the delivery technology it’s using to transport large molecules into the CNS, detailing a differentiated strategy for hijacking the transferrin receptor. The company revealed features of its large molecule...

With a $30 million series A round led by Andreessen Horowitz, Octant is using genetic bar codes to sort out the pathways behind the therapeutic effects of dirty GPCR modulators, and developing new agents with...

While not every biotech can develop countermeasures for COVID-19, nearly all can contribute by providing urgently needed resources to protect the clinicians and other essential workers holding the line against catastrophe, and by making their...

Deploying its HPV serology testing lab to validate COVID-19 assays is one of three ways NIH’s National Cancer Institute is retooling cancer research activities to take on the pandemic. In a virtual advisory committee meeting...

To inform public health measures to control the novel coronavirus outbreak, the U.K. has launched the COVID-19 Genomics UK Consortium to track viral spread and evolution via genome sequencing of COVID-19 samples. The group, with...

It makes sense that CRISPR-Cas13 would enter the limelight during the COVID-19 crisis, given that the SARS-CoV-2 is an RNA virus, and this Cas enzyme targets RNA. With diagnostics one of the most critical components...