Biokine, BioLineRx preclinical data

In vitro, BL-8040 alone and in combination with imatinib directly inhibited cancer cell growth and induced apoptotic cell death of CML cells. In a mouse model of CML, tumor burden was significantly reduced by 56% with 10 mg/kg imatinib alone, 46% with 400 µg BL-8040 alone, and 95% with 400 µg BL-8040 plus 10 mg/kg imatinib vs. saline-treated controls (p<0.01 for all). BioLineRx said BL-8040 reversed the protective effect of the bone marrow stroma on CML cells. Data were published in Molecular Cancer Therapeutics. ...