Aeolus preclinical data

Aeolus reported data from rats with pilocarpine-induced neurotoxicity showing that subcutaneous AEOL 10150 given 30 minutes prior to or 60-90 minutes after exposure to pilocarpine inhibited markers of oxidative stress and neuronal damage. The company said final results from the rat study, which are expected in 2H13, will determine whether AEOL 10150 should be developed under FDA's Animal Rule as a countermeasure against nerve agents. The Animal Rule allows marketing approval to be granted based on efficacy in relevant animal models and an acceptable safety risk profile in humans. NIH's Countermeasures Against Chemical Threats Research Network (CounterACT) funded the study. ...