Mesoblast preclinical data

In sheep with collagen-induced arthritis, a single IV injection of 2 million MPCs/kg led to significant mean reductions compared to saline-treated controls of 88% in IL-6 (p=0.029), 83% in tumor necrosis factor (TNF) alpha (p=0.049), 53% in IL-17 (p=0.005) and 52% in infiltrating macrophages (p=0.009). Additionally, MPCs significantly reduced mean histopathology severity scores by 31% vs. controls (p=0.025). Mesoblast plans to start Phase II testing of the allogeneic adult mesenchymal precursor cells used to expand cord blood by up to 40-fold to treat RA in 4Q12. ...