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    E.g., 2018-02-20
    E.g., 2018-02-20

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13798 items
5:19 PM, Feb 15, 2018  |  BC Innovations | Product R&D

Banking on the placenta

Celgene Corp. spinout Celularity Inc. is aiming to disrupt the stem cell market with a platform of placenta-based cell therapies whose intrinsic allo-tolerance could provide a broadly applicable system for propelling off-the-shelf cancer therapies into...
5:09 PM, Feb 15, 2018  |  BC Innovations | Strategy

Pfizer’s chemistry machine

With the goal of creating a step-change in the optimization of small molecules in discovery research, Pfizer Inc. has built a continuous flow machine that rapidly tests thousands of chemical reactions using submilligram quantities of...
1:35 PM, Feb 15, 2018  |  BC Innovations | Emerging Company Profile

Cultural shift

Microbiotica Ltd. has combined high-precision sequencing, a large reference database and novel culturing approaches to identify and develop commensal bacterial strains, including previously unculturable ones, to treat Clostridium difficile infection and other bacterial-associated gut indications. Microbiotica’s...
4:04 PM, Feb 14, 2018  |  BC Innovations | Translation in Brief

Gut check

A Nature study from New York University has shown the T cell regulator MAF determines whether the intestinal immune system of mice responds to certain bacteria with a protective Treg population or a pro-inflammatory Th17...
4:03 PM, Feb 14, 2018  |  BC Innovations | Translation in Brief

The DRAGEN and the genome

By analyzing a whole genome in under 30 minutes, Edico Genome’s DRAGEN Bio-IT platform is helping to push Genomics England towards achieving its goal of sequencing 100,000 whole genomes and making genomic sequencing a staple...
1:25 PM, Feb 14, 2018  |  BC Innovations | Translation in Brief

Poring over pain

Harvard Medical School researchers have figured out how to hijack the pores formed by bacterial toxins on nerves to deliver normally membrane-impermeable compounds into the cells and treat pain the pathogens cause. While the January study...
12:49 PM, Feb 14, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Neurofibromatosis Patient sample and mouse studies suggest c-MET inhibitors could help treat neurofibromatosis type II. In neural tissue from patients, level of c-MET mRNA were higher in neurofibromatosis type II schwannomas than in unaffected nerves....
4:57 PM, Feb 13, 2018  |  BC Innovations | Distillery Techniques

Assays and screens

TECHNOLOGY: Cellular assays; high throughput screening A high throughput yeast-based method of antibody screening could help identify therapeutic antibodies in human blood. The method involves three steps: engineering a yeast strain with cell-surface expression of a...
4:56 PM, Feb 13, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Addiction Mouse studies suggest inhibiting RGS20 could help treat morphine addiction. In periaqueductal gray samples from morphine-treated mice, levels of RGS20 protein were higher than in samples from vehicle-treated mice. In mice treated with intraperitoneal...
4:55 PM, Feb 13, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Pain Cell culture and mouse studies suggest inhibiting S. aureus AgrA or activating TRPV1 could help treat S. aureus-induced pain. In co-cultures of mouse dorsal root ganglion cells and S. aureus, knockout of S. aureus...

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