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    E.g., 2018-09-24
    E.g., 2018-09-24

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8:53 PM, Sep 20, 2018  |  BC Innovations | Product R&D

China’s rising genomics start-ups

Behind bellwethers BGI Genomics Co. Ltd. and WuXi NextCode Genomics Inc., a new generation of Chinese genomics companies is emerging with ambitions to solve urgent problems, including early cancer detection and clinical trial recruitment, by...
6:21 PM, Sep 20, 2018  |  BC Innovations | Tools & Techniques

Precision for pancreatic cancer

Real-time sequencing and organoid-based screens in pancreatic cancer could place new targets and biomarkers in the hands of drug developers looking for ways to side-step KRAS, a gene mutated in 90% of patients. Because KRAS...
12:37 PM, Sep 20, 2018  |  BC Innovations | Emerging Company Profile

Recalcitrant Targets

With a fresh take on small molecule microarray technology, Kronos Bio Inc. aims to identify small molecule inhibitors of oncology targets considered undruggable, starting with a splice variant of the androgen receptor expressed in metastatic...
8:24 AM, Sep 20, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Melanoma Cell culture studies identified an inhibitor of Q209L-mutant Gα-q that could help treat uveal melanoma harboring the mutation. In HEK cell-based signaling and activity assays, a previously reported cyclic depsipeptide-based inhibitor of Gα-q inhibited...
8:24 AM, Sep 20, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Cervical cancer Patient sample, cell culture and mouse studies suggest inhibiting USP7 could help treat cervical cancer. In cervical samples from 20 patients, levels of USP7 mRNA were higher than in samples from healthy volunteers,...
8:23 AM, Sep 20, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Cervical cancer, esophageal cancer, head and neck cancer, lung cancer Cell culture and mouse studies suggest inhibiting the long non-coding RNA (lncRNA) CCAT1 could help treat squamous cell carcinoma (SCC) of the cervix, esophagus, head...
8:22 AM, Sep 20, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Prostate cancer In vitro and cell culture studies identified a peptide-based PCSK6 inhibitor that could help treat prostate cancer. Chemical synthesis and in vitro testing in binding assays of analogs of a previously identified octapeptide...
8:21 AM, Sep 20, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Acute myelogenous leukemia (AML) Patient sample, cell culture and mouse studies suggest inhibiting VEGF-C could help treat AML. In bone marrow samples from pediatric patients, levels of VEGF-C were higher than in samples from healthy...
8:21 AM, Sep 20, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Prostate cancer Patient sample and cell culture studies suggest inhibiting BDNF-TrkB signaling could help treat prostate cancer in African-American patients. In prostate fibroblasts isolated from four African-American patients, levels of BDNF were higher than in...
8:20 AM, Sep 20, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Colorectal cancer; leukemia Cell culture and mouse studies suggest promoting phagocytosis mediated by CALR-asialoglycan binding could help treat colorectal cancer and leukemia. In two human colorectal cancer and two human leukemia cell lines co-cultured...

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