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SciBX: Science-Business eXchange
As published Thursday, April 17, 2014

  • Cover Story: Contaminating cancer genomes

    By Chris Cain, Senior Writer

    Contaminating cancer genomes

    Two European teams have pinpointed the DNA-protective enzyme 7,8-dihydro-8-oxoguanine triphosphatase as a chemically tractable target whose inhibition kills cancer cells by accelerating DNA damage.1,2 Both groups have identified collections of small molecule inhibitors of the enzyme-one of which is an isomer of cancer drug Xalkori crizotinib-and both are looking to partner with industry.

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  • This Week in Techniques

    Isoacyl dipeptides to increase insulin yield from chemical synthesis; binary nylon-3 copolymers containing cationic and hydrophobic subunits for antimicrobial activity; markers of distinct SHH-driven medulloblastomas; and more...

  • more techniques news
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