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7:00 AM GMT, Aug 15, 2005
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Tools & Techniques

Pathogen sensors

The Toll Collectors

Pathogen sensors

Toll-like receptors are transmembrane proteins that were discovered nine years ago in Drosophila when scientists noted that knockout flies lacking TLR genes lost their immunity to fungal infections. In humans, 12 TLRs have been reported, though the twelfth has not been described.

TLRs are expressed by immune cells,

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This article and the information contained in BioCentury's publications and services are solely for your own personal, non-transferable licensed use and cannot be shared with any other individuals. For information about adding subscribers to your account or obtaining article reprints, please contact support@biocentury.com.