BioCentury
ARTICLE | Tools & Techniques

Sarepta's hemorrhagic mouse

January 24, 2013 8:00 AM UTC

A team at Sarepta Therapeutics Inc. has developed a mouse model of arenavirus infection that recapitulates key symptoms of the disease including hemorrhagic fever and multiorgan failure.1 The researchers now want to use the mice to study the Lassa arenavirus.

Arenavirus infection symptoms vary from virus to virus, but general symptoms are fever, malaise, body aches and rash. For arenaviruses that cause hemorrhagic disease, symptoms also include low platelet count, internal and external hemorrhage and multiorgan failure.2...