BioCentury
ARTICLE | Cover Story

Trends with benefits

November 14, 2013 8:00 AM UTC

The FDA set up its adverse event database decades ago to capture the side effects of marketed drugs, but a group from the Icahn School of Medicine at Mount Sinai has now exploited the millions of entries to extract a different type of information-beneficial drug combinations that statistically reduce a drug's risk of toxicity. The positive interactions could reveal nodes at which pathways intersect, providing new targets to help guide drug discovery.

"Our strategy was to ask what if combining drugs could have some good effects," team leader Ravi Iyengar told SciBX...