Prothena jumps on Phase I data for NEOD001

Prothena Corp. plc (NASDAQ:PRTA) jumped as much as $7.59 (22%) on Wednesday before closing the day up $3.21 (10%) to $36.95 on interim data from an ongoing Phase I trial of NEOD001 to treat amyloid light-chain (AL) amyloidosis. Five of nine evaluable patients had undisclosed reductions in levels of N-terminal pro-brain natriuretic peptide (NT-proBNP). Lower levels of that marker indicate increased cardiac function. Three patients had stable levels. Cardiac function is the major determinant of survival for AL amyloidosis patients. ...