Challenging the textbooks

Papers published last week on three novel pathways in angiogenesis, cell signaling and Parkinson's disease provide new therapeutic strategies and illustrate the rewards of continuing to explore well-trod territory.

One example is cell signaling, which has been studied in detail for about 50 years, as researchers have gradually revealed new participants in the old pathways. The accepted wisdom was that signaling is mediated by a phosphorylation process in which phosphate groups are added to or plucked from proteins by ATP

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