12:00 AM
Nov 12, 2001
 |  BioCentury  |  Tools & Techniques

Taking NSAIDs into Alzheimer's

There is a growing body of epidemiological evidence that non-steroidal anti-inflammatory drugs lower the risk of Alzheimer's disease. A paper in last week's Nature supports those data, but also concludes that while existing NSAIDs may lower risk, the doses required for therapeutic use were too high to provide a satisfactory safety and efficacy profile.

In addition, the mechanism by which NSAIDs work in AD remains a mystery. It now appears that while the anti-inflammatory properties of NSAIDs may play a role, the primary effect is through processing of amyloid plaque precursors.

Working in cultured cells, scientists from the University of California at San Diego, the Mayo Clinic Jacksonville and colleagues examined the...

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