ARTICLE | Product Development
Betting Combos on Biomarkers
Pharmacodynamic biomarkers are driving IO combos in absence of monotherapy responses
November 17, 2018 3:21 AM UTC
Despite lackluster monotherapy data at SITC from the latest tranche of immunotherapy candidates, drug developers are moving into combination trials with PD-1 and PD-L1 inhibitors based on biomarkers of pharmacodynamic activity. Results from the next randomized controlled trials putting that rationale to the test could be another year away.
The annual Society for Immunotherapy of Cancer (SITC) meeting yielded a deluge of Phase I data from single-agent and combination studies of immunotherapy agents against new targets. The goal is to find the next combination partner for PD-1 or PD-L1 inhibitors that can augment the average 30% response rate of the now standard-of-care agents in solid tumors. ...