BioCentury's websites will be down for upgrades starting at 9 p.m. PDT on Monday, August 26. We expect the downtime to last no more than 6 hours, and we apologize for any inconvenience.

12:00 AM
 | 
Aug 17, 2009
 |  BioCentury  |  Product Development

Heating up the airways

Asthmatx Inc. believes its Alair bronchial thermoplasty system will significantly improve quality of life for patients with severe asthma who are not adequately served by drugs. If successful, the treatment would be added on to standard therapies like inhaled corticosteroids and bronchodilators and would compete with late-stage treatments like oral steroids and Xolair omalizumab.

A PMA is under review at FDA for the device to treat adults with severe asthma, with an advisory committee meeting expected this year. The MDUFMA date is not disclosed.

Asthmatics have thickened airway smooth muscle, which constricts and narrows the airway during an asthma attack. The Alair system uses a bronchoscope and catheter to deliver controlled radiofrequency energy to the walls of the airway for 10 seconds, which causes reduction of the smooth muscle. The company's theory is that this would reduce the ability of the airway walls to contract and narrow in response to an allergen or irritant.

The outpatient procedure is done under conscious sedation and takes about 40 minutes. The procedure is done three times about three weeks apart: once each for the upper, middle and lower third of the lungs.

"Many procedures that do this burn tissue. We are delivering energy at a very low level, generating...

Read the full 1021 word article

User Sign in

Trial Subscription

Get a 4-week free trial subscription to BioCentury

Article Purchase

$150 USD
More Info >