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12:00 AM
May 19, 2008
 |  BioCentury  |  Product Development

Metastatic target in the basement

Although researchers discovered in 1984 that the laminin receptor precursor/laminin receptor (LRP/LR) is overexpressed in tumor tissue compared with normal tissue, until recently there has been minimal interest because a basement membrane receptor involved in cell communication and adhesion didn't seem to be an attractive target.

Researchers from Affimed Therapeutics AG and colleagues have now shown that antibodies against LRP/LR inhibit the two key components of metastatic tumors: invasion and adhesion.

Laminin, a glycoprotein of the extracellular matrix or basement membrane, is an integrin-like protein that under normal conditions plays a role involving interactions between cells, such as attachment, migration and differentiation. LRP forms a dimer to become the LR. In solid tumor cells, both LRP and its mature...

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