Based on data reported last week, investors concluded that Lucentis from Genentech Inc. and Novartis AG will be the winner over Eyetech Inc.'s Macugen in the treatment of wet age-related macular degeneration (AMD). But EYET is arguing that the patient populations and protocols in the studies - and by extension the results - are not comparable.
DNA (South San Francisco, Calif.) and Novartis (NVS; SWX:NOVN, Basel, Switzerland) reported that after one year, about 95% of patients given Lucentis ranibizumab in a Phase III trial lost less than 15 ETDRS letters, or 3 lines, in visual acuity compared to about 62% in the control arm, the primary endpoint (p<0.0001).
Patients given Lucentis also significantly improved mean visual acuity, a secondary endpoint, while controls experienced a decrease.
Patients in the