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12:00 AM
Mar 07, 2005
 |  BioCentury  |  Product Development

VLA-4 biology

Rethinking the Target

VLA-4 biology

Integrin alpha(4) beta(1), also known as VLA-4 (very late antigen 4), has been considered an attractive target because of its role at a key step in the inflammatory process. VLA-4 is expressed on lymphocytes, monocytes and eosinophils, but not on neutrophils.

In inflammation, white blood cells are recruited to diseased or injured tissue in a multi-step mechanism. Mediated by several cell adhesion molecules, leukocytes are slowed down and start rolling along the blood vessel wall. Upon activation by chemokines, the adhesion molecules on leukocytes are...

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