The Heart of Inflammation
The involvement of inflammation in the etiology of coronary artery disease has led to the development of anti-inflammatory compounds to prevent or treat atherosclerosis and acute coronary syndrome. As yet, there is no conclusive evidence from a large, controlled trial showing the clinical benefit of a cardiovascular compound specifically designed as an anti-inflammatory. However, results from recent statin trials indicate that their anti-inflammatory activity plays a significant role in improving clinical outcomes, thus lending support to the hypothesis.
Statins inhibit the activity of HMG-CoA reductase - a rate-limiting enzyme in the synthesis of cholesterol - resulting in decreased intracellular cholesterol. In turn, this leads to the upregulation of LDL receptor activity, which ultimately