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Oct 09, 2006
 |  BioCentury  |  Politics, Policy & Law

Valid biomarkers

Valid biomarkers

Biomarker Drug Selected label content
C-kit expression Gleevec imatinib (Novartis) Gleevec inhibits proliferation and induces apoptosis in gastrointestinal stromal tumor (GIST) cells, which express an activating c-kit mutation
CYP2C19 variants Vfend voriconazole (Pfizer) Studies indicate that CYP2C19 is involved in the metabolism of Vfend
CYP2C9 variants Celebrex celecoxib (Pfizer) P450 2C9 (CYP2C9) poor metabolizers should be given Celebrex with caution as they may have abnormally high plasma levels due to reduced metabolic clearance
CYP2D6 variants Strattera...

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