Ebb & Flow

But investors keep returning. This quarter, ISIS has attracted both a new face (Symphony Capital) and a familiar one (Acqua) to its story. Both investors say their due diligence suggests a strong pipeline of second-generation antisense compounds aimed at big indications.

Last week, Azimuth Opportunity, which is advised by Acqua Capital, made a $75 million equity financing commitment to the company. Acqua is no stranger to ISIS, having invested in the company’s $27.3 million private placement in March 2000. ...