Cullgen: boosting the breadth of E3 ligases for protein degradation

Cullgen is expanding the toolbox of E3 ubiquitin ligases that can be used to target and degrade cancer-associated proteins by looking beyond widely used ligases.

With its ubiquitin-mediated, small molecule-induced targeted elimination (uSMITE) technology, Cullgen Inc. is developing small molecules that link disease-causing proteins to previously untapped E3 ubiquitin ligases in the cullin ring family, which recruit ubiquitin to induce proteasome-mediated degradation. ...