Cullgen: boosting the breadth of E3 ligases for protein degradation
How Cullgen is expanding the repertoire of E3 ligases used in protein degradation
Cullgen is expanding the toolbox of E3 ubiquitin ligases that can be used to target and degrade cancer-associated proteins by looking beyond widely used ligases.
With its ubiquitin-mediated, small molecule-induced targeted elimination (uSMITE) technology, Cullgen Inc. is developing small molecules that link disease-causing proteins to previously untapped E3 ubiquitin ligases in the cullin ring family, which recruit ubiquitin to induce proteasome-mediated degradation.
“The cullin ring family of E3 ligases are fairly ubiquitous across