BioCentury
ARTICLE | Emerging Company Profile

Enterin the gut

How Enterin’s compound could help treat Parkinson’s disease constipation

May 11, 2018 8:39 PM UTC

Enterin Inc. has a new twist on the longstanding Parkinson’s disease target alpha synuclein. The biotech is inhibiting the protein’s accumulation in intestinal nerves rather than in the brain, with the goal of treating constipation and non-motor symptoms associated with the disease.

Alpha synuclein (SNCA) is a major component of Lewy bodies, a type of protein aggregate that builds up in the brains of PD patients. But the protein is also expressed in the gastrointestinal (GI) tract, and accumulates in intestinal nerves during the disease...