12:00 AM
Sep 12, 2016
 |  BioCentury  |  Emerging Company Profile

Age factors

Why Alkahest thinks plasma factors are key to fighting age-related diseases

Alkahest Inc. is identifying factors in human plasma that could serve as therapeutics or novel targets used to treat age-related conditions, including Alzheimer's disease.

The newco's work stems from the lab of co-founder Tony Wyss-Coray, a Stanford University professor of neurology who demonstrated that injecting plasma from old mice into young mice impaired spatial learning and memory and decreased neurogenesis. Those data were reported in Nature in 2011.

In the same paper, Wyss-Coray and colleagues identified six plasma factors, including chemokine CC motif ligand 11 (CCL11; eotaxin-1) and beta-2 microglobulin (B2M), that correlated with decreased neurogenesis in aged mice as well as young mice who had been exposed to blood from aged mice via heterochronic parabiosis. Under that procedure, old and young mice are surgically connected so that they share a circulatory system.

The researchers also showed that systemic administration of CCL11 in young mice also impaired learning and memory and decreased neurogenesis.

In a 2014 Nature...

Read the full 830 word article

User Sign in

Trial Subscription

Get a 4-week free trial subscription to BioCentury

Article Purchase

$150 USD
More Info >