Straightening out sickle cell

Imara Inc.'s phosphodiesterase-9 inhibitor, IMR-687, is a potentially disease-modifying candidate for sickle cell disease that could avoid the toxicities and dosing challenges associated with more advanced products.

Sickle cell disease is a genetic disorder that causes red blood cells to make abnormal hemoglobin, which polymerizes when deoxygenated, distorting the cells into a sickled shape. ...