Swallowing large molecules
Rani's oral capsule injects large molecule drugs into the intestine
Researchers have been working on oral delivery of peptides and antibodies for decades with limited success. Rani Therapeutics LLC is taking a different approach, with an orally delivered, pH-activated capsule that uses sugar needles to inject large molecule therapeutics into the muscle of the intestine.
Chairman and CEO Mir Imran said most attempts to create oral formulations of large molecules have focused either on blocking degrading enzymes in the GI tract, or on modifying drug molecules so