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12:00 AM
Jun 29, 2015
 |  BioCentury  |  Emerging Company Profile

Swallowing large molecules

Rani's oral capsule injects large molecule drugs into the intestine

Researchers have been working on oral delivery of peptides and antibodies for decades with limited success. Rani Therapeutics LLC is taking a different approach, with an orally delivered, pH-activated capsule that uses sugar needles to inject large molecule therapeutics into the muscle of the intestine.

Chairman and CEO Mir Imran said most attempts to create oral formulations of large molecules have focused either on blocking degrading enzymes in the GI tract, or on modifying drug molecules so they are not sensitive to the enzymes, and then trying to improve intestinal absorption. He noted there have been some successes, but only with short peptides up to about 20,000 Da in weight, and these products have had low oral bioavailability.

"We said these are injectable drugs, why don't we inject them in the mucosal muscle?" said Imran.

Rani developed a capsule that houses sugar needles containing a dry formulation of the therapeutic, plus two chambers containing...

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