ARTICLE | Emerging Company Profile
Building macrolides
How Macrolide's synthetic chemistry could make more effective macrolides
April 13, 2015 7:00 AM UTC
Macrolide Pharmaceuticals Inc. is using a synthetic chemistry platform to generate novel macrolide antibiotics with improved efficacy over macrolides derived from natural products. The company is focusing on Gram-negative pathogens.
The first macrolide antibiotic, erythromycin, was isolated from bacteria over 50 years ago. Successive macrolides have been derived from erythromycin and are widely used for Gram-positive infections. ...