Vasomune: Lassoing Tie2
Vasomune's vasculotide activates Tie2 to treat acute kidney injury
Agonizing Tie2 could restore vascular integrity and limit tissue damage in kidney injury, but bringing together the four copies needed to activate the receptor is a job too big for small molecules or antibodies. Vasomune Therapeutics Inc. has shown its four-armed peptidomimetic, vasculotide, activates Tie2 and restores vascular integrity in mouse models.
"Many renal diseases are ultimately characterized by a loss in vascular integrity that damages tubules in the kidney," CEO Parimal Nathwani said. "Our idea